At least seven people, including three siblings, were killed in separate landslides in Kalaghata and Lemujiri areas of Bandarban early Tuesday.The fire service officials said two people were still missing in one of the landslide incidents.The identities of the four victims — Reba Tripura, 22, Mitu Barua, 5, Shuvo Barua, 4, and Lata Barua, 2 — have been known immediately.Quoting local people, the fire service officials said a house in Kalaghata area of the district town was hit by a landslide around 1:00am on Tuesday, killing college student Reba Tripura, and injuring Bir Bahadur Tripura, 18, Proshen Tripura, 24, and Babylon Tripura.House of a certain Mohammad Aziz in Lemujhiri’s Jelepara area was also hit by a landslide where Aziz’s wife Kamrunnahar, 40, and their daughter Sukhia akhtar, 14, went missing at about 2:00am on Tuesday. But, Aziz managed to escape the incident.Bandarban Sadar union parishad (UP) chairman Sabukhoi Marma said one Lal Mohan Barua’s house also collapsed in a landslide. Mohan Barua’s three children were killed in the incident around 4:00am on Tuesday.Lal Mohan Barua said the landslide took place when the couple went to clean the drain near their home during the rainfall.Bandarban fire service station official Shapan Kumar Ghosh said a search is going on rescue the missing.
The BBC has unveiled plans to air “the most complete digital coverage of a Winter Olympics Game to date,” with more than 650 hours of live action from Sochi 2014 to be offered online through six HD streams.Announcing its plans for the Russian games, the BBC said it aimed to build on the digital success of its coverage of the London 2012 games by offering analysis, insight, news and highlights from Sochi 2014 to audiences across any device.All six live streams will be available through the BBC’s Connected Red Button service on Virgin Media TiVo and Sony Freeview Smart TVs and via the BBC Sport app for connected TVs.Viewers can also access coverage from the BBC Sport website, which is accessible on PCs, tablets and mobiles, or on the free BBC Sport app for iOS and Android mobiles and tablets.In terms of linear coverage, the BBC said it will air 200 hours of the games on network TV, plus two red button streams.“BBC Sport is very proud to be able to offer such extensive coverage from Sochi 2014 – after delivering London 2012 we’re once again at the forefront of bringing the most innovative and accessible multi-platform sports coverage to our audiences,” said Ron Chakraborty, lead executive of major events for BBC Sport.Coverage starts with the Winter Olympics Opening Ceremony, which will be broadcast live on BBC Two and BBC Two HD from 3.30pm on February 7.
Sky Mexico has tapped Amazon Web Services-owned Elemental Technologies to power its over-the-top video service.Sky Mexico is using Elemental’s software-based video solutions as the processing engine for Blue To Go Video Everywhere, which first launched in 2014.Available to subscribers of Sky Mexico’s satellite pay TV services, the OTT service now has the capacity to stream as many as 30 live events simultaneously to connected devices across the country.
The second mouse gets the cheese. If you lend someone $20 and never see that person again, it was probably worth it. Always keep your words soft and sweet, just in case you have to eat them. The Federal Reserve is, of course, a bank. So after it has a meeting, it issues a statement outlining the discussion – a “bank statement.” Hmm… Now that I think about it, that must be where the acronym “BS” comes from. Notwithstanding what we read and hear, when Congress established the Federal Reserve as a central bank 100 years ago, its primary purpose was to protect the banking system. The Federal Reverse shifted risk from the private sector to the public, and through the slow devaluation of the dollar, the cost of this shift fell on the average Joe rather than on banking tycoons. Today, an entire generation is paying for this system with a good portion of their life’s savings. I pride myself on explaining complex financial situations in everyday language. However, when it comes to the Federal Reserve, I readily admit that I am sometimes befuddled. I used to watch Alan Greenspan testify before Congress when he was Chairman of the Fed, and I often ended up asking myself, “What did he just say?” The Fed’s code and doublespeak is Greek to me, as it is to most folks. But I do know this: The carefully crafted reports and publications are designed to send messages and move markets in the direction the Fed wants. After the minutes of a recent Fed meeting prompted the Bloomberg headline Fed Signals Possible Slowing of QE Amid Debate Over Risks, it should come as no surprise that the dollar strengthened and gold and silver tanked. The Fed’s message certainly had its desired effect! Since Vedran Vuk already decoded the message in a recent Casey Daily Dispatch, we know there may not be a reason to celebrate a return of the dollar’s strength quite yet. Basically, the Fed is going to continue on its current course despite what newspaper headlines may suggest. (In addition to helping the Money Forever portfolio make some double-digit gains, Vedran has an extraordinary gift for explaining all things technical. We’re lucky to have him as our resident message decoder.) Let’s take a quick look at what Vedran had to say, and then consider what it means for seniors and savers. Despite the fancy headlines and the market reaction, Vedran concluded: “There was a discussion of possible risks, but at the end of day, that’s all it was, a simple discussion. Although several members expressed concerns in the discussion, when it came down to voting on the actual policy, only a single member dissented.” Despite the rhetoric, it’s clear that not much is going to change in the foreseeable future. Just more BS from the Fed, without much being done to reduce spending. Vedran went on to directly quote the minutes of the Fed’s meeting: “In 2014 and 2015, real GDP was projected to accelerate gradually, supported by an eventual lessening of fiscal policy restraint, increases in consumer and business sentiment, further improvements in credit availability and financial conditions, and accommodative monetary policy.” In his usual fashion, Vedran cuts through the BS: “Umm… wait; what ‘eventual lessening of fiscal policy restraint’? Essentially, the Fed is saying that as economic conditions improve, the American voter will stop complaining, and the government can finally get back to spending wheelbarrows of money. It’s scary to think that these additional government spending plans are already reflected in the Fed’s GDP projections…” Now let’s get this straight: The government will continue to devalue the dollar, keep interest rates artificially low, spend at a rate that would put Caligula to shame, and simply hope that US citizens and the G20 nations don’t get angry about it. And in the meantime, the Russians and Chinese are taking their new high-value dollars and buying gold hand over fist. Great plan!Risky Business Let’s take another look at an excerpt on risk from the minutes: “In general, after having been depressed for some time, investor appetite for risk had increased. A few participants commented that the Committee’s accommodative policies were intended in part to promote a more balanced approach to risk-taking, but several others expressed concern about the potential for excessive risk-taking and adverse consequences for financial stability. Some participants mentioned the potential for a sharp increase in longer-term interest rates to adversely affect financial stability and indicated their interest in further work on this topic.” I’ll let Vedran tell us what in the heck that means: “So what does ‘excessive risk-taking and adverse consequences for financial stability’ mean? The next sentence on long-term interest rates offers a clue. Participants warn of a ‘potential for a sharp increase in longer-term rates.’ Sure, a sharp upward turn in rates would hurt just about everything, including the stock market, but the sectors that will get hurt the most are real estate and bonds.” Hang on a minute here. Back in 2007, we had nice, juicy 6% CD rates. My portfolio earned interest income equal to five times the amount of my Social Security check. Moreover, my money was at very little risk since CDs are FDIC insured. Today, if I were foolish enough to invest in CDs, my interest income would equal half of my Social Security check. While I agree that a sharp increase in interest rates could be a problem, I sure wouldn’t mind seeing them go up slowly. It would be nice to have interest rates three times higher than the rate of inflation – like they used to be. Now, I know we older folks are told we have to make sacrifices, but this is ridiculous. Didn’t this mess start with banks taking excessive risks by lending money to people who could not afford to pay it back? Isn’t that where the phrase “toxic loans” came from? I’d say the first Troubled Assets Relief Program (TARP) that bailed out these banks was an excessive risk. To top it off, the banks then called in CDs, wiping out a source of safe investment income many retirees had come to depend on. The Fed followed that up with Quantitative Easing (QE) that flooded the banks with money at the expense of seniors and savers. Meanwhile, our taxes are going up because politicians keep babbling, “We must do something about the deficit.” Well, perhaps that’s because they used our tax dollars to bail out the banking system. Retirees are being attacked on three fronts: higher inflation, higher taxes, and lower yields, and I’m fed up.Fed Up with the Fed We recently conducted a survey on inflation and price increases with our friends at Casey Daily Dispatch. Regular readers already know that the Money Forever Reader Poll Inflation Rate is 8%. I’ll refer readers back to my recent article, Reading the Tea Leaves, for a complete breakdown of the math; for now, note that if a retiree wants to earn 4% on his portfolio to supplement his Social Security income and 8% to keep up with inflation while holding 30% of his portfolio in cash (as we recommend), he must earn 17.1% on the other 70% of his portfolio. That’s no small order. So it turns out that the “excessive risk” has been transferred to seniors. To earn a 17.1% return, we have to take far more risks than we’d like. Instead of investing in safe instruments like CDs or long-term Treasuries that once offered good interest rates, we have to seek out riskier investments to make ends meet. Seniors can’t risk a big blow to their portfolios, but ultra-conservative investing is no longer an option. This is one of the reasons many seniors are turning to junk bonds. There was a time when retirees wouldn’t touch a junk bond with a ten-foot pole, but now many feel forced into them. Too many seniors live in fear as they tap into their principal and drain their life savings. Others are cutting back on expenses and returning to work, often at far less glamorous jobs than they once had. It is not a pretty picture. And yes, I find it maddening that “too big to fail” banks are once again paying out large bonuses to their executives at our expense. Goldman Sachs reinstated its annual Partners Dinner in New York City last Friday; while I’m not one to boo-hoo a good party, a blowout, black-tie gala sure seems in poor taste. I suspect the partygoers slept a lot better in their Champagne-induced comas than many baby boomers and retirees did that night. I can only imagine what that little affair cost. The excessive risks banks took during the real estate boom have been successfully transferred onto the backs of the taxpayers, seniors, and savers. Each month the Federal Reserve meets and issues a BS report. They word it to fool the public, but thanks to Vedran we can decode their BS. I won’t be fooled, and I refuse to let our readers be fooled either. —- Frankly, I’m tired of the BS from the Fed, Wall Street, bankers… you name it. Based on the number and tone of letters our readers send in, you are too. Do they really think our generation is that stupid? We’ve seen a thing or two in our time, and we know what’s really going on. OK, the rules have changed. Now we have to take risks in order to survive… and hopefully thrive. Nevertheless, we can manage those risks responsibly to earn the income we need to make sure our nest egg lasts and we sleep soundly at night. And that is exactly what we are doing. That’s why I started Miller’s Money Forever: to give my generation the truth about our situation and the tools to take control of our retirement finances. I’d like you to consider taking charge of your retirement today with a no-obligation trial subscription to Miller’s Money Forever. Please click here to learn more.On the Lighter Side I can’t be the only person who is fed up with all the “fiscal cliff” threats. Our government has automatic spending increases scheduled every year. That way, when they decide not to spend as much – but still more than last year – politicians and pundits can call it a spending cut. Maybe no member of Congress or the executive branch should be eligible for reelection unless we have a truly balanced budget with no accounting mumbo-jumbo. I suppose that is called dreaming the impossible dream. —- Well, we made it to Arizona for spring training, and we are already having fun. I’m surprised at how many of our friends have settled here for the winter. On Thursday, 50 of us are gathering to watch the game in Surprise. Of course we’ll all have dinner together after the game, but I suspect that our bill for 50 seniors’ dinners will be a tiny fraction of the cost of the Goldman Sachs Partners Dinner. And finally… our good friend Snow wrote to share some simple lessons on life. Accept the fact that some days you’re the pigeon, and some days you’re the statue! Nobody cares if you can’t dance well. Just get up and dance. And my favorite: When everything’s coming your way, you’re in the wrong lane. Until next week…
Reviewed by James Ives, M.Psych. (Editor)Oct 26 2018Belgian research groups from the UCLouvain and WELBIO, VIB and Ghent University, and the biotechnology company argenx elucidated the three-dimensional structure of an assembly of proteins operating on cells that dampen immune responses. They also discovered how an antibody can block this assembly and the immunosuppression it induces downstream. Such an antibody could serve to stimulate immunity against tumor cells in cancer patients, triggering the destruction of their tumors by immune cells. The study is published in the authoritative journal Science.Immunosuppression through a cascade of interactionsTregs (regulatory T lymphocytes) are immunosuppressive cells that normally counterbalance excessive immune reactions to prevent autoimmune diseases. But in cancer patients, they play deleterious roles by tempering immune reactions against tumor cells. Tregs induce their effects by producing a protein messenger called TGF-beta. This messenger transmits inhibitory signals to immune cells in the immediate vicinity, notably those that are supposed to destroy tumors in cancer patients.The way Tregs produce TGF-beta is complex and finely regulated, because TGF-beta is very potent and must be kept under tight control. Three years ago, Prof. Sophie Lucas and her team at the de Duve Institute of the UCLouvain discovered that TGF-beta is released by Tregs from a protein called GARP, present on the Treg surface. In collaboration with argenx, her team also discovered that it was possible to block the release of TGF-beta from GARP with specific antibodies, which were rare and difficult to obtain. The next thing to find out was how GARP regulates the production of the TGF-beta messenger and how antibodies actually block its release.The molecular mechanisms elucidatedTo address these questions, Sophie Lucas and argenx initiated a collaboration with the team of Prof. Savvas Savvides at the VIB-UGent Center for Inflammation Research, to resolve the three-dimensional structure of the protein assembly made of GARP and TGF-beta. The researchers used X-ray crystallography, a method that has been used to study the structure of molecules for more than a century and that is still being developed for the study of biological macromolecules at atomic resolution. However, they were confronted with the practical problem that they could not readily obtain crystals of the GARP and TGF-beta complex. Via a highly collaborative effort spearheaded by Dr. Stéphanie Lienart (UCLouvain) and Dr. Romain Merceron (VIB – Ghent University), the two teams decided to use a blocking antibody to stabilize the structure – a successful approach that not only helped to generate suitable crystals for structure determination, but also provided details about how a therapeutic antibody might function.Related StoriesBacteria in the birth canal linked to lower risk of ovarian cancerStudy reveals link between inflammatory diet and colorectal cancer riskStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryProf. Savvas Savvides (VIB-UGent): “We discovered that GARP resembles a horseshoe that is straddled by TGF-beta. The two molecules are so intricately assembled that TGF-beta itself contributes to the structure of the GARP horseshoe. The antibody fragment sticks to both GARP and TGF-beta in the assembly. It appears to glue the two molecules to one another, ensuring that when other molecules pull on one part of the assembly, the small, active part of TGF-beta is not released, and is thus prevented from conveying its inhibitory message.”Prof. Sophie Lucas (de Duve Institute at the UCLouvain): “Visualization of this large molecular assembly illustrates the feasibility of blocking TGF-beta activity emanating from a precisely defined and restricted cellular source, such as the surface of Tregs. This can lead to the design of exquisitely specific approaches to treat various diseases associated with altered TGF-beta or Treg activity, most notably for the immunotherapy of cancer.” Source:http://www.vib.be/en/news/Pages/Belgian-researchers-discover-a-novel-method-to-block-immunosuppression-in-cancer.aspx
Reviewed by James Ives, M.Psych. (Editor)Jul 17 2019The Damon Runyon Cancer Research Foundation has named four outstanding young scientists as recipients of the prestigious Damon Runyon-Sohn Pediatric Cancer Fellowship Award, committing nearly $1 million to help address a critical shortage of funding for pediatric cancer research.The Fellowship Award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers. Each recipient receives a four-year award totaling $231,000. Since 2012, this award has supported 31 innovative pediatric cancer researchers who were selected by a prestigious committee of leading pediatric oncologists in a highly competitive process.Related StoriesResearch sheds light on sun-induced DNA damage and repairHow cell-free DNA can be targeted to prevent spread of tumorsUsing machine learning algorithm to accurately diagnose breast cancer”The program provides critically needed support for innovative young investigators working on high impact pediatric cancer research. We need their brilliant minds focused on curing childhood cancers,” says Andrew L. Kung, MD, PhD, Chair of the Damon Runyon-Sohn Pediatric Cancer Fellowship Award Committee, and Chair of the Department of Pediatrics, Memorial Sloan Kettering Cancer Center.Because cancer occurs less frequently in children and young adults than in the adult population, pediatric cancer research does not receive significant funding from either the National Cancer Institute (only four percent of its budget) or the biopharmaceutical industry. To help fill this gap, The Sohn Conference Foundation, dedicated to curing pediatric cancers, partnered with the Damon Runyon Cancer Research Foundation, the leading charity supporting brave and bold young cancer researchers, to establish the award. The Sohn Conference Foundation has committed nearly $3.2 million to the program to date. The award program continues to receive additional funding and recognition within the philanthropic community. Our Damon Runyon-Sohn fellows are committed to making daring discoveries in pediatric cancer pathology. We place our bets on funding bold and innovative ideas from emerging scientists, as they hold the promise of advancing treatment and cures for children with cancer.”Evan Sohn, Sohn Conference Foundation Source:Damon Runyon Cancer Research Foundation
Explore further University of Otago researchers are demonstrating the potential of a new technology which could see New Zealand production of a popular food – the French fry – become healthier, and less costly and wasteful. Recently arrived pulsed electric field (PEF) processing equipment will be put to test for large scale French fry production over the next three months.This technology, which uses brief pulses of electricity (microseconds) to modify and disrupt the membranes of cells in plant or animal material or microorganisms, has a wide variety of applications across many food processing industries. The electric field being pulsed through un-cut potatoes during processing alters their microstructure, which results in a more controlled release of sugar, more uniform colouration and reduced oil uptake. It also enhances processing as the softer texture makes the potatoes easier to cut, meaning there is less waste, the ability to develop new shapes (e.g. lattice cut) and increased knife durability (up to 60 per cent).As pulsed electric field processing affects the cell membrane it can be used to enhance the extraction of pigments or bioactive compounds from food, increasing their yield and quality or to kill micro-organisms as alternative to the pasteurisation of bulk liquids, such as fruit juices and milk. Citation: Pulsed electric field technology offers new potential for food processing (2018, June 28) retrieved 18 July 2019 from https://phys.org/news/2018-06-pulsed-electric-field-technology-potential.html French fries derived from a potato processed through this new Pulsed Electric Field (PEF) processing machine are healthier for people to eat. Credit: University of Otago This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Provided by University of Otago Credit: University of Otago The industry pilot programme is part of a Ministry for Business and Innovation funded Food Industry Enabling Technology (FIET) programme worth nearly NZ$16.8M, over a six-year period (2015-2021). There are six institutions involved in the programme: Massey University (host), the University of Otago, the University of Auckland, Plant & Food Research, AgResearch and the Riddet Institute. The University of Otago leads the research and industry implementation of PEF technology.”With the equipment now in New Zealand we are excited to begin the industrial trial with the hope of proving the techniques, and in time enabling New Zealand food industries to benefit from this new technology,” says University of Otago Professor Indrawati Oey, Head of Otago’s Department of Food Science and the PEF project leader.”PEF also has potential to enhance the quality and value of many other NZ agricultural and horticultural products,” adds Professor Oey. Researchers developing next-generation sanitisers to control bovine mastitis in the dairy industry