A Harvard Stem Cell Institute (HSCI) study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant of shifts in their energy supply than their normal counterparts. The results suggest there could be ways to target and kill cancer cells without affecting healthy cells.HSCI scientists at the Massachusetts General Hospital Center for Regenerative Medicine and the Harvard University Department of Stem Cell and Regenerative Biology led the work, in collaboration with researchers at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. The work was described in an article published today in the journal Cell.“It’s been known for decades that cancer cells use energy differently than most cell types,” said senior author David Scadden. “So we thought, maybe there are metabolism differences between blood stem cells and their immediate descendants. And are they so different from cancer that you might be able to manipulate energy sources with something that could have an effect on cancer and not harm normal cells?”Scadden’s team began by examining blood stem cells and their direct offspring: blood progenitor cells that have a more limited ability to differentiate. The researchers modified the way the cells took up nutrients in two ways: via a glucose (sugar) on-off switch, and through subtle adjustments that raised or lowered glucose like a volume dial. The researchers found that turning off the glucose switch caused stem cells to die, while dialing up the glucose volume affected normal energy production in the offspring cells, in some ways for the better.“That was an interesting distinction between these two cell types,” said Scadden, the Harvard University Gerald and Darlene Jordan Professor of Medicine. “They have very different functions, and you might imagine they’re going to use their nutrients very differently, but nobody had defined that before.”The investigators next introduced genes that had been corrupted to cause the parental blood stem cells and their offspring to become cancerous (these respectively give rise to chronic and acute leukemia), and subjected the cancer cells to the same glucose manipulations as their normal counterparts. The team found that regardless of which cell they started in, the leukemia cells were sensitive to both the glucose on-off switch and the volume dial.“One of the major hurdles for cancer therapy is that while the drugs are effective in killing cancer cells, they are toxic to normal cells,” said study first author Ying-Hua Wang, a postdoctoral fellow in the Scadden Lab. “In this study, we found a way to differentiate sensitivity between normal and malignant cells, suggesting a potential therapeutic angle.”“Cancer cells are not like normal cells in a lot of ways, but one … is that they get locked into a particular way of behaving,” Scadden said. “These cells are so singular in the way they handle glucose that they create a unique opportunity to intervene. Normal cells don’t get so disrupted because they have other energy mechanisms in place.”Private companies have been developing drugs that target cancer metabolism, but primarily in solid tumors. Scadden hopes that this study can open the door to industry partnerships and the generation of new treatments. More research will be needed to determine whether non-blood cancers have similar differences in metabolism sensitivity.The study was highly collaborative, including work and insights from Professor Matthew Vander Heiden and graduate student William Israelsen at Massachusetts Institute of Technology; Clary Clish, Broad Institute director of the Metabolite Profiling Platform; and cancer biologist Lewis Cantley of Weill Cornell Medical College.The work was funded by the National Institutes of Health, the American Cancer Society, Massachusetts General Hospital, the Proton Therapy Research and Treatment Center, BD Biosciences, a Bullock-Wellman Fellowship, a Tosteson & Fund for Medical Discovery Fellowship, the Smith family, the Stern family, the Burroughs Wellcome Fund, the Ludwig Foundation, and the Damon Runyon Cancer Research Foundation.
Russ Anderson at the southern terminus of the A.T.On his quest to thru-hike the Appalachian Trail, Russ Anderson of Linville, N.C., has endured hypothermic conditions, Army rangers with machine guns, and bears that know how to get food bags out of trees. Not bad for a 71-year-old retiree who’d never spent a night on the A.T. before deciding to hike it from end to end.How much of the A.T. have you hiked so far? I’m 178.5 miles in. I started in Springer, made it to the Nantahala Gorge, then skipped the Smokies and hiked into Damascus. This summer, I hope to start in Damascus and head north, then come back to do the Smokies in the winter.Is it as tough as everyone says? It’s like six or seven hours of extreme manual labor. Even if you’re 25 years old, it’s difficult. Those first days in Georgia were tough. Foggy, drizzling rain, cold, hail, sleet, freezing winds. Once I arrived at a shelter, I stripped off my rain gear and got into my sleeping bag. It took two hours to get warm again. But it’s worth it. The trail itself, the people I’ve met…it’s worth it.What does your wife think about you thru-hiking the A.T.? She doesn’t like it. A person my age is supposed to be the leader of a family. I’m not supposed to disappear for six months. In a sense, I feel like I’m cheating the people in my lives. My wife and I are empty nesters, so she’s alone when I’m out there hiking. Even my friends think I’m crazy. They say I’m going to get eaten by a bear or fall off a cliff.What made you decide to undertake this hike? I’m a retired naval officer. My life has been filled with unusual adventure. I just need more of that. Only 11 people over 70 have ever thru-hiked the A.T. And none of them had tried hiking it for the first time over 70. So that got me interested.What’s been your most memorable moment on the trail so far? My second night out, I was sleeping in a shelter with 10 other people. All of a sudden, I hear a big explosion. Then machine gun fire. Then I hear yelling and shouting. None of us knew what was going on. Everybody was wicked scared, thinking the Russians were coming or something. Turns out, we were in the middle of an Army Ranger training exercise. We sat there for two hours while things blew up all around us. 1 2
I recently shared something on my Facebook feed that seemed to draw attention.It was a simple graphic that talked about the three gates of communication. I’m not sure where it came from. Some say ancient Greece. Some say Buddha. And there are other claims as well. I’ll put aside where it came from for the moment because I think the message was powerful – at least to me.When speaking or communicating, your words must pass three gates before you can share them.Is this true?Is this necessary?Is this kind?There are days when I think I’d be reduced to hand gestures by these gates! A few thoughts.The first gate is simple. Enough said.The second? It is tough. I’ve tried to focus on this at home. My kids are…kids. They make mistakes. Is it necessary to correct them every time? I don’t think so. At work, am I adding value with a comment? Or just trying to have everyone know how smart I am? This gate is a work in progress for me!The third gate is very difficult. Can everything be kind? Constructive feedback. Negotiations. This is also a work in progress for me. But I think we can all do this: Start with eliminating things that are intentionally unkind. 10SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Anthony Demangone Anthony Demangone is executive vice president and chief operating officer at the National Association of Federal Credit Unions (NAFCU). Demangone oversees day-to-day operations and manages the association’s education, membership, … Web: https://www.cuinsight.com/partner/nafcu Details
“The mental health aspect, has really hit home. and that’s been our number one concern is making sure the kids are okay,” she says/ “It was very emotional for me,” said Murat, “because I really miss being around my students and having the life they bring to my classroom.” Murat says some aspects have gotten easier, and more than ever, she’s doing more than just teaching her lesson plans. School has been closed for nearly two months, and distance learning continues to be an adjustment on both sides of the screen. “It’s just hard, for them [students], as well as the staff that’s at the school,” says Murat. Binghamton School District students submitted videos showing their appreciation. To view the video click here! Maine-Endwell Senior High teacher and New York state Teacher of the Year, Rachel Murat said Friday’s announcement from Governor Andrew Cuomo was difficult to process over the weekend, calling it a “crushing blow.” When school can return, Murat said she is most looking forward to her classroom being full of life, and is leaving her students with some advice for the time being. As for the curriculum changing, Murat said “there’s definitely going to be gaps. Especially in the elementary school, there’s going to be a larger summer slide so we absolutely are going to have to adjust our curriculum.” “If this is the worst thing that happened all day, it’s going to be a great day, and this is obviously something that is very impactful for our students and our families but I know we can get past it and move on and get back to the plans we did have.” This is a week to celebrate teachers, as today kicks off Teacher Appreciation Week! Murat says when school (hopefully) returns in the fall, there will be new adjustments to make. “Unfortunately I don’t think we can necessarily go exactly back to what we were doing.” “Like” Nicole Menner on Facebook and “Follow” her on Twitter. Afton Elementary school also did its part with two videos. Click here to see students thanking teachers, and click here to see teachers thanking school families. TOWN OF UNION (WBNG) — Teachers across New York State are grappling with the news they won’t be returning to the classroom at any point this academic year.
Red Bull and Honda protege Yuki Tsonoda completed the 300km towards F1 superlicence in wet and dry conditions at Imola; Tsunoda, third in the F2 standings, is being evaluated for a possible AlphaTauri drive in the 2021 season next to Pierre Gasly By James GallowayLast Updated: 04/11/20 6:52pm – Advertisement – Japan’s Yuki Tsunoda has made his debut behind the wheel of a Formula 1 car ahead of a possible full-time drive with AlphaTauri next year.The F2 driver, who is third in the feeder series’ standings, completed a first test at Imola with the team’s 2018 car on Wednesday amid changeable conditions.Tsunoda, 20, is a member of Red Bull’s young driver programme and also backed by Honda, who supply engines to both AlphaTauri and Red Bull until the end of next year.- Advertisement –
Oil prices extended gains Thursday after Russia signaled it was ready to cut output before a key producers’ meeting aimed at boosting energy markets as the coronavirus pandemic strangles demand.US benchmark West Texas Intermediate rose 4.6 percent to US$26.26 a barrel, while Brent crude, the international benchmark, jumped 2.7 percent to $33.73.Read also: Chinese oil refiners to lift April production to 2019 levels Oil exporting group OPEC, led by top producer Saudi Arabia, and others – including Russia – will meet via video conference later Thursday and expectations are growing they will agree to reduce output to support prices.Prices are at near-two-decade lows with travel restrictions and lockdowns around the world throttling demand, and Riyadh and Moscow locked in a vicious price war.But Saudi Arabia and Russia, the world’s second-biggest producer, now look set to draw a line under their dispute to help stabilize battered markets.Moscow said Wednesday it is willing to cut output by about 1.6 million barrels a day, or about 15 percent, Bloomberg News reported, smoothing the path towards a deal. A key question had been whether the US would join any deal, but analysts say a fall in America’s crude output forecast released earlier this week is likely enough to satisfy Riyadh and Moscow for now. Another key meeting takes place Friday, when G20 energy ministers hold talks remotely to discuss steps to steady the market.Read also: Pertamina to go ahead with higher oil production plan despite oil price crashStill, analysts caution that the devil will be in the detail, and an output cut deemed too small could send prices down even further.A cut of just 10 million barrels a day “might not trigger much of rally and probably eventually see selling pressure drive crude back to the low-mid $20s”, said Edward Moya, senior market analyst with OANDA.He also cautioned that a “turn for the worse could happen” which derails a deal, adding that “the following 24 hours will be critical for global oil prices”.Topics :
Unlike many countries, tests are widely available in China. Ben Cowling, an infectious disease specialist at Hong Kong University, said he expects many organizations in China to arrange regular screenings of staff.”Testing is expensive, but perhaps not as expensive in China because the reagents and machines tend to be produced in China,” he said.”It’s also not as expensive as local or city-wide lockdowns might be, if outbreaks became larger before being identified.”Nationwide build-upHundreds of bidding documents issued by hospitals and centers for disease control (CDC) in every province since the beginning of May list requirements for new testing labs, painting a picture of a fast-paced national program.The most expensive items are polymerase chain reaction (PCR) machines, a key testing component documents show can cost up to $99,000.Chinese organizations bought 257 PCR laboratories in the last 30 days, according to listings on procurement platform Jianyu360, compared with an average of 21 per month in the previous 12 months.Those figures represent a fraction of the total, as not all projects are detailed in public procurements.For over two weeks after the virus was identified in January, no hospitals in Wuhan – a city of 11 million – were equipped to conduct tests, meaning no new cases were confirmed until days before the city’s lockdown.Most of the new labs are being installed in hospitals, and most cost between 100,000 and 3 million yuan ($15,000-$420,000).Some institutions require all equipment to be produced within China, though others call for specific foreign-made gear, including PCRs made by Switzerland’s Roche Holding AG and US-based Bio-Rad Laboratories Inc.Price controls on testsChina has said it can produce 5 million test kits a day, and provincial governments have imposed strict price controls on manufacturers.Hubei province, the epicenter of the outbreak, compels test makers to cut prices for bulk orders, driving them as low as 16.78 yuan for a nucleic acid test, and 12.9 yuan for an antibody-based kit, according to figures released on May 9.Medical institutes will be barred from offering tests if they refuse to buy kits from the few companies that secured contracts at government-negotiated prices, Hubei authorities said.China does not say how many tests it has conducted, but the figure is widely believed to far surpass other countries. By comparison, the US CDC reported over 20 million tests conducted as of June 5.”I think everyone will take the tests, even many tests,” said Lu Meiping, one of thousands of university students set to return to Beijing this month under quarantine and testing programs.”No one wants to stay home.” On Monday, the National Health Commission said it would look to “normalize” nucleic acid testing.”If they’re willing to be checked, check them all,” said the policy notice.Life is increasingly returning to normal in China, where the outbreak first emerged in the city of Wuhan late last year.Last month, Wuhan tested around 6 million people over 10 days at a cost of 900 million yuan ($127 million), an initiative some experts said largely had the benefit of boosting confidence. Topics : China is building hundreds of testing laboratories and stocking up on tests to ramp up screening for the coronavirus, even in healthy people, having all-but stamped out local transmission of the disease.China is looking to make testing universal, available in every corner of the mainland.Procurement documents and official notices show it is sharply expanding its testing capability, already the world’s largest, extending it even to rural health facilities as it looks to revive the economy after an unprecedented plunge in the first quarter.
German financial services company Commerzbank has returned its regulatory licence to conduct business concerning ship Pfandbriefe as part of its plan to dispose of bad shipping loans.Namely, in an effort to get rid of a portfolio of EUR 4.5 billion of shipping loans, the bank returned the licence with effect from May 31, 2017.Commerzbank said it has not issued any ship Pfandbriefe, securities backed by shipping mortgages, for the last six years, and does not intend to do so going forward.According to § 2 para 3 Pfandbriefgesetz (PfandBG), the cover pool for ship Pfandbriefe has to be phased out, once the licence has expired. In this context, the Federal Financial Supervisory Authority (Bundesanstalt für Finanzdienstleistungsaufsicht) granted Commerzbank AG an exception regarding the statutory limit under the PfandBG for further cover assets “in order to allow Commerzbank additional flexibility for the onward downsizing of its discontinued ship financing business.”From June 1, 2017, ship Pfandbriefe issued by Commerzbank can be completely secured by such further cover assets used for public Pfandbriefe.In the light of the ongoing reduction of its ship financing portfolio, Commerzbank will make use of the exceptional permission and intends to replace all ship finance loans collateralized by ship mortgages in the cover pool by such further cover assets used for public Pfandbriefe in the course of this year.
The PMA also announced that swimmingclasses would remain suspended until it has placed all the needed safetymeasures. Swimming teachers Robert Bete andAntonio Catalan were found “negligent and imprudent” during the swimming sessionthat led to the death of Cadet Fourth Class Mario Telan Jr., the PMA on Fridaysaid. MANILA – The Philippine MilitaryAcademy (PMA) announced that two of its swimming teachers were sacked followingthe Nov. 8 drowning of a cadet. “The PMA is committed to leaving nostone unturned on the case of Cadet Fourth Class Telan, and will continue toinstitute measures for the safety of all cadets so that this tragic incidentwill not be repeated,” the PMA said. Sanctions for two Fourth Class Cadetmarchers who failed to account their classmates before and after the swimmingclass are still being discussed, it added. It is also arranging to have a teamfrom the Philippine Navy Special Operations Group to be part of all water-bornetraining activities of the Cadets.(With areport from ABS-CBN News/PN) Both Bete and Catalan are barred fromholding public office and from taking the civil service examinations. They haveyet to comment on the PMA’s decision.
GREENSBURG, Ind. — The Indiana Department of Transportation plans to resurface US Highway 421 in Greensburg this spring and summer.Work will also include the installation of 51 ADA-compliant curb ramps.Crews will repair and resurface the highway between Wilder Street to just south of State Road 3.There will be closures starting in June to pave the section between Main Street and the bypass.Preparations for the project will begin on Tuesday.