Even though they can make some people uncomfortable, disagreements and arguments are a critical part of business. Without disagreements and arguments you get groupthink, and you end up with mediocrity. When you have constructive conflict and disagree about what is right, you get a chance to explore new ideas, even ideas that make some people uncomfortable.But constructive conflict needs to be done in a way that is safe and beneficial to the organization. “Safe” means it can’t harm the individuals that make up the organization.Assume good intentions: When someone disagrees with the way something is being done and engages with others around that issue, it is imperative that you assume that person has good intentions. By assuming they have good intentions, you can shift your focus to the value of the idea, instead of evaluating the individual who is brave enough to bring up the idea.Don’t blame people for mistakes, problems, or challenges: A personal review is something different from constructive conflict, even though it might include some constructive conflict. When you blame the individual for the mistakes, the challenges, or the problems your business is experiencing, you cause people to operate from a place of fear. If you have to operate from fear, you are going to avoid constructive conflict because the repercussions are likely bad for you. Blaming people keeps organizations from solving their deepest problems, and it keeps them from growing.Focus on generating new ideas, withholding judgment about any idea: When you do have constructive conflict, it’s easy to dismiss another person’s ideas without giving them a fair hearing. You can very quickly get to all the reasons that something can’t or shouldn’t be done. But this isn’t how you solve problems. You solve problems when you generate new ideas and explore them before you choose one.The healthiest cultures invite arguments and disagreements. A culture that is strong can withstand the idea of change. There are no sacred cows that must be protected. And every issue is seen as an opportunity to grow, not something to be avoided because egos are too fragile or feelings too easily hurt. Constructive conflict is necessary, and it’s incredibly valuable when done well. Get the Free eBook! Want to master cold calling? Download my free eBook! Many would have you believe that cold calling is dead, but the successful have no fear of the phone; they use it to outproduce their competitors. Download Now
Your competitor might have a better product or a better price. You might believe that gives them a competitive advantage, but it doesn’t have to. You can tilt the playing field in your direction. Work Ethic: You can outwork your competitor. Honestly, it isn’t really going to be all that difficult to do. Most people do what is required of them, not what they need to do to succeed. Your commitment to out-hustle your fiercest competitors alone is enough for you to win. Do the work they won’t do. Do that work when they are sleeping.People Skills: A person with better people skills can develop the relationships that level the playing field—and level their competitors. The ability to connect, the fact that you are likeable, and the fact that you care can create a preference. All things being equal, being good with people is a serious advantage.Business Acumen: A better student of business makes a better salesperson. By educating yourself on your business, your client’s business, and the economy more generally, you are likely to know how to create greater economic outcomes. Greater business knowledge and experience is a competitive advantage.Trustworthiness: Following up on your commitments creates a sense of trust. So does knowing what you are talking about. Being client-focused and working as if you are already part of your client’s decision-making team creates a gap between you and any competitor that doesn’t generate the same level of trust.Patient Persistence: The willingness to stay the course long after it seems a lost cause levels the playing field, especially when it comes to winning your dream clients. There is a strong advantage in outlasting your competitors. Patient persistence doesn’t mean you hang back. It means you keep taking action over time and, eventually, you win.Better Sales Skills: Knowing how to sell will never hurt you. Sales acumen is still incredibly important in creating a competitive advantage. Winning by intention instead of through a series of happy accidents is what separates the professionals for the amateurs, and it can tip the balance in your favor in a contest.Desire to Win: There is no accounting for the desire to win. It is the kind of intangible that appears to be some kind of voodoo. There is something about heart, guts, and the will to win that gives someone who is fighting above their weight class an advantage in a contest. Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Now
The ruling Janata Dal (United) on Tuesday removed Satish Kumar as vice-president of its Bihar unit for “anti-party activities”. Mr. Satish Kumar had criticised some senior leaders for convincing JD(U) president and Chief Minister Nitish Kumar to withdraw from contesting the Uttar Pradesh Assembly elections. “Satish Kumar has been removed from the post of JD(U) State vice-president,” party chief spokesman and MLC Sanjay Singh said. He said Sanjay Mandal was removed as State organisational secretary for the similar reason.Mr. Satish Kumar, a former MLA from Nalanda, was close to Mr. Nitish Kumar. He was credited with organising the ‘Chetna’ rally, the biggest ever by the Kurmi community, in Bihar in 1994. After the rally, Mr. Nitish Kumar was projected as a Kurmi leader, and he parted ways with Lalu Prasad. Mr. Satish Kumar was put in charge of the party in UP after the JD(U) decided to contest the Assembly polls.. Mr. Nitish Kumar addressed over six public meetings in UP. All of a sudden, the party withdrew from the contest.
Union minister Kiren Rijiju has said Chakma and Hajong communities cannot be granted Scheduled Tribe status in Aunachal Pradesh.“The issue of Chakma and Hajong is very sensitive and we cannot grant them Schedule Tribe status in Arunachal Pradesh. I have also filed an affidavit in Supreme Court on the matter” the Union Minister of State for Home Affairs said.On the issue he would do his best in his capacity at the central level, Mr. Rijiju said at the two-day state executive meeting of the BJP in the city on Thursday.On the Assam – Arunachal boundary issues, Mr. Rijiju said that he had already written to the ministry concerned and chief ministers of both Assam and Arunachal Pradesh should come forward with an amicable solution.He also said that the construction of a four-lane NH – 415 would soon be a reality and for that the central government had already assured to provide an extra package, a party release said here on Friday.
Railway Minister Suresh Prabhu on Sunday directed the Chairman of the Railway Board to fix responsibility on “prima facie evidence by the end of day” into the derailment of the Utkal Express in Uttar Pradesh.The minister said he was monitoring the situation closely and that restoration of tracks was his top priority.Over 20 people died after 14 coaches of the Utkal Express derailed near Muzaffarnagar in western Uttar Pradesh yesterday evening. “Restoration is top priority. Seven coaches tackled. Also ensuring best possible medical care for the injured. Monitoring situation closely,” he said in a tweet.“Will not allow laxity in operations by the Board. Have directed CRB to fix responsibility on prima facie evidence by end of day,” he tweeted.The minister, who has been keeping a close tab on the situation since yesterday, directed senior officials and medical personnel to provide assistance to injured passengers and all possible help to relatives of affected passengers.Mr. Prabhu had ordered an inquiry into the derailment yesterday. He said he was personally monitoring the situation and strict action will be taken in case of any lapse.The minister also announced ₹3.5 lakh ex-gratia compensation for those who lost their lives, ₹50,000 for the seriously injured and ₹ 25,000 for those who received minor injuries.
Kashmir witnessed a shutdown on Monday over the National Investigation Agency’s (NIA) move to summon Kashmir Traders and Manufacturers Federation (KTMF) president Yasin Khan and Kashmir University scholar Aala Fazil to New Delhi for questioning in an “illegal funding case”.Several supporters of Mr. Khan held a silent sit-in in Lal Chowk against his summoning. The NIA had asked Mr. Khan to asked present himself before the NIA on Monday.“We would continue our peaceful protest until Yasin sahab leaves the NIA headquarter,” said a protesting trader.The shutdown call by traders, supported by separatists, impacted the daily life in the Valley. There was a thin traffic on the roads as educational institutions, petrol pumps and banks remained closed. The authorities placed areas under five police stations in the old city under restrictions. Train service in south Kashmir was also stopped. Hurriyat faction chairman Mirwaiz Umar Farooq said, “The NIA is resorting to coercive and intimidating tactics against people of Kashmir”.NIA raids continueMeanwhile, the NIA on Monday continued with its raids in Kashmir Valley.Police sources said two youth, one from Ganderbal and another from Baramulla, were questioned regarding their involvement in stone pelting.The NIA has registered a case in May regarding illegal funding from across the border to fuel violence in J&K. Seven separatist leaders are already in the NIA custody.Court grants bail to Jamaat-e-Islami spokesmanThe high court on Monday granted bail to Jamaat-e-Islami (JeI) spokesman Zahid Ali Lone.“Freedom of speech and expression is the soul of our democratic and secular fabric. The might of our great India is not so weak that by using a few nonproductive and ego satisfying slogans the people will be scared even by a grain of fear that their levies will be put at a peril,” said Justice M. K. Hanjura, while granting bail.Lone’s lawyer Salih Pirzada said his client was arrested on August 4 “for raising slogans.” The police had alleged Mr. Lone’s objecting was “to induce the youth of the adjoining areas to indulge in rioting and join the militant ranks to accomplish the ultimate aim of seceding Jammu and Kashmir from the Union of India”.
Justice Jayant Patel, former acting Chief Justice of Gujarat High Court and currently a judge in the Karnataka High Court has resigned from the Service. Though Justice Patel has not cited any reason for tendering resignation, sources said he was apparently unhappy since he was not made the Chief Justice in any High Court despite his seniority, and even after the Supreme Court Bar Association and the Gujarat High Court Bar Association have in the past raised the issue of his elevation as Chief Justice. It may be noted that as a senior judge of the Gujarat High Court, Justice Patel had ordered CBI probe in the controversial fake encounter of Ishrat Jahan and three others and monitored the case for more than six months.It was during his monitoring that the CBI filed charge sheet in the case naming top officials of the Intelligence Bureau (IB) and the Gujarat police for staging the fake encounter. In Karnataka High Court, he was due for elevation as Chief Justice or Acting CJ but was instead transferred to Allahabad High Court where he was to be the third senior-most judge. Justice Jayant Patel sent his resignation to the Chief Justice’s office and the same has been accepted.
Four women were feared drowned after a boat, carrying nine members of a family, capsized in the Ganga in rural Patna on Wednesday, police said.Five others – two men and three women – could be rescued.The boat was carrying members of the family based in Gaya district, who had come here to take a holy dip on the occasion of Magh Purnima, SHO Naseem Ahmed told PTI.The incident took place at around 10 am in Fatuha police station area.Efforts were on to trace the missing persons, the SHO said.
Haryana’s principal Opposition party, the Indian National Lok Dal (INLD), on Monday asked the Centre to take steps for an early completion of the Sutlej-Yamuna Link (SYL) canal. Leader of the Opposition in Haryana Assembly Abhay Singh Chautala-led delegation met Union Water Resources Minister Nitin Gadkari and impressed upon him the early completion of the SYL canal as directed by the Supreme Court. They also requested him to urge the Haryana government to follow the Supreme Court directive regarding compensation to the farmers whose land is to be acquired for the Dadupur-Nalvi canal and continue with the project.Mr. Chautala drew the attention of Mr. Gadkari to the fast depleting ground water in the State. “As it is, South Haryana has already become ‘dark zone’ and a worried Supreme Court has put restrictions on construction. North Haryana, the basmati bowl of the State, too has slipped in the ‘critical’ zone. Thus almost the whole of the State is sliding towards ‘dark’ zone and hence would become infertile and desert due to unavailability of water,” he said. This would have serious repercussions on the social and economic front, he added.Mr. Chautala said that Mr. Gadkari assured them that if the Dadupur-Nalvi canal project were scrapped, the Centre would contribute towards meeting the additional expenses.
The police in Belonia have arrested two people, including a former CPI(M) activist who had switched over to the BJP, in connection with the demolition of a statue of Vladimir Lenin on Monday. Based on video evidence, three others have been sent notice to appear before the police by Friday. Belonia, about 90km from State capital Agartala, is the headquarters of South Tripura district bordering Bangladesh.Video footageThe arrests on Wednesday came amid revelation that one of five people seen in the video footage pulling down the Lenin statue with bulldozer had taken the lead in demolishing a statue of former Prime Minister Indira Gandhi – also in Belonia.This man, Manik Das, is a contractor who left Tripura during the 1988-1993 Congress rule and returned after the Left Front won the 1993 polls to allegedly terrorise Congress workers.“Manik Das is one of three people we have summoned under Section 41 of CrPC. The others are Suman Mazumdar, owner of the bulldozer and one Uttam Saha. They are expected to report within 48 hours,” Ipper Monchak, West Tripura district Superintendent of Police, told The Hindu.“We have already arrested the bulldozer driver and Raju Nath on basis of evidence gathered,” he said.
Mumbai: Pune-based real estate developer Kohinoor Group which has forayed into student housing segment through its start up entity Youthville Serviced Hostel, is planning a major expansion to cater to the growing need for quality hostel facility for students in education hubs across the country.The company’s maiden property in Pune is a girl’s hostel with a capacity of 150 beds. A second property with a capacity to house 600 students will be opened in Pune next year.“By 2019- 2020 we will be acquiring additional 600 beds and another 600 beds will be added the following year. By 2023- 24 we are aiming to have 25,000 beds pan-India,” said Vineet Goyal,Founder, Youthville Serviced Hostel.He said student housing was highly under-supplied across the country and students lack basic hygiene, food and other necessities.“At present student housing is functioning in an unorganised manner. Students are deprived of basic facilities, making their lives difficult. At Youthville we have addressed these inadequacies and created space where students can live comfortably,” Mr. Goyal said. “Student housing is in huge demand worldwide,” he added. Given the fact that student housing demand will stay strong in the future, the segment will be propitious for investors and real estate developers,” Mr. Goyal added.Currently the venture is funded by Kohinoor Group and the company is looking for investors to meet the expansion plans.Pune with steady rise in the student population has huge demand for student accommodation. Hostels charge between ₹97,000 to ₹2 lakh per student per year. Youthville charges ₹1,35,000 per bed in triple sharing basis per year and ₹1,83,000 in twin sharing accommodation.Along with accommodation the company provides high speed Wi-Fi, laundromat, fitness centre,cafeteria, music room, library, mini theatre, common kitchenette, doctor on call and housekeeping facility.Students need to pay for their food and transport. The company has also made provision for bike on hire.As per HRD ministry data there are about 35 million students currently studying in colleges and universities across the country. About 11 million of them come from other states to pursue higher education. These are the students who are under the radar of companies providing hostel facilities.
The state-wide shutdown called by the Congress and other opposition parties against rising fuel prices received a lukewarm response in the State.While Maharashtra Navnirman Sena (MNS) workers damaged a Pune Municipal Corporation bus in the city’s Kumthekar road area in the morning, it was business as usual for most shops and establishments across the city.Most petrol pumps, however, remained shut for security reasons. Schools and colleges continued to function normally. Robust security ensured that commute was not hit in Pune city. The Congress, NCP and MNS, took out major rallies.NCP MP Supriya Sule led the rally in Pune while senior Congress leader Radhakrishna Vikhe-Patil headed his party’s protest in Ahmednagar district. The ‘bandh’ received a marginally better response in Solapur district, with shops in Pandharpur taluk downing shutters in support of the shutdown. Bus services, however, were thrown awry in Nashik.The protest fared better in Marathwada. Protests and sit-ins were observed throughout Aurangabad, Beed and Jalna whereCongress workers were seen raising slogans against the Modi government, and mocking the BJP-led NDA for the sky-rocketing fuel prices.
Jammu and Kashmir Chief Electoral Officer Shaleen Kabra on Saturday announced the dates of elections to the urban local bodies in the State despite a boycott threat by the regional parties. The National Conference and the Peoples Democratic Party described the decision as “unfortunate”.“The municipal polls will be conducted in four phases on October 8, 10, 13, 16,” Mr. Kabra said.There urban local bodies have remained without members due to repeated deferment of [elections], owing to growing militancy and rising civilian casualties in the past few years. These polls will be followed by the panchayat polls that will begin in November,” he said.“The elections to two municipal corporations, three municipal councils and 72 municipal committees in the State shall be held from October 8 to 16. The last elections to the municipal bodies were held in 2005 and their five-year term expired in 2010.”He said the EVMs would be used for the elections. “Of 1,145 wards, 90 wards have been reserved for the Scheduled Castes and 38 wards have been reserved for the Scheduled Tribes, which includes 31 and 13 wards reserved for SC and ST women. Around 322 wards have been reserved for women belonging to the open category,” he said.Kashmiri migrants will be allowed to vote through postal ballot. Around 17 lakh voters will particiapte in these polls.Protests continueThe decision to hold these polls comes despite the NC and the PDP announcing to stay away from the urban local bodies and panchayat polls in J&K, asking the Centre to clear its stand on Article 35A, which defines State Subject laws, before the Supreme Court.PDP spokesman Rafi Mir told The Hindu: “It’s an unfortunate decision. We were expecting that Governor Satya Pal Malik will hold an all-party meeting. It seems the decision was taken without taking public or political parties’ opinion on board. We stand by our decision to stay away from these polls.”NC general secretary Ali Muhammad Sagar said these polls would have no credibility. “Unfortunately, no one was taken into confidence while announcing these polls. Such polls will serve no purpose and will only damage the idea of democracy. Any election is held to allow parties and people to participate. We saw three militants being killed in Jammu on Friday and five people, including a civilian, being killed on Saturday. In such an atmosphere, what message is the Centre giving by holding these elections,” Mr. Sagar asked.
Congress president Rahul Gandhi on Friday targeted Prime Minister Narendra Modi, saying he can’t leave aside his public relations exercise even for five minutes.The Congress chief was addressing a public rally in Dhule district of north Maharashtra.“Our prime minister tells the media that India is united after the Pulwama terror attacks, but immediately targets Congress,” Mr. Gandhi said.“India’s prime minister can’t leave aside his public relations [exercise] even for five minutes. That is the difference between him and us,” Mr. Gandhi said.The Congress leader accused Mr. Modi of misusing solemn occasions to target the Congress.“He [Modi] does the same [engage in PR exercise] at the war memorial opening,” Mr. Gandhi said, referring to Mr. Modi opening an all-out attack on the Congress during the opening ceremony of the National War Memorial in Delhi recently.Mr. Gandhi also ridicules Anil Ambani on the Rafale aircraft deal, saying the industrialist can’t even make a paper plane.Slamming Mr. Modi over the Rafale deal, Mr. Gandhi said under the Chowkidar’s watch, Rs 30,000 crore went into Anil Ambani’s pockets.
The animal that kills the most humans worldwide isn’t the shark, lion, or grizzly bear: It’s the mosquito. In 2012, about 200 million people developed malaria after being bitten by the insect; some 600,000 died, 90% of them in Africa and most of them children under 5. The slippery parasite that causes the disease has long defied efforts to develop a vaccine. But a study of malaria-resistant children in Tanzania has turned up an antibody that helps stop the infection in its tracks. Based on this antibody’s actions, scientists have developed a preliminary vaccine that shows promise in mice.The parasite that causes malaria is a single-celled organism called Plasmodium. It might as well have been designed by a diabolical mad scientist, says Jonathan Kurtis, an immunologist at Brown University and senior author of the new study. When an infected female mosquito bites a human, the microbe enters the victim’s bloodstream and makes for the liver, where it multiplies by the tens of thousands. From the liver it goes back into the bloodstream, infecting and multiplying inside red blood cells. Eventually it bursts out again, in a form called a schizont — infecting more blood cells and re-entering the bloodstream to infect the next hungry mosquito, in whose body it goes through a cycle even more complex. The bursting-out stage, which occurs about every 24 hours, produces the fever, chills, and aches that make the patient so miserable. “It’s like the worst flu you’ve ever had,” Kurtis says.Because different proteins are produced in each stage of the microbe’s cycle, Plasmodium presents a shifting target for potential vaccines. So far, the most promising candidate is one dubbed RTS,S. In a phase III clinical trial reported in late 2012, this vaccine, which works by reducing the amount of infected liver cells, led to a 50% decrease in the number of severe symptoms and blood levels of the parasite in children aged 5 months to 17 months.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)But even in malaria-stricken areas, some people have only mild symptoms or none at all, and they may show only minimal levels of the parasite in blood samples. To find out why, Kurtis and colleagues compared the blood of people who are resistant to those who aren’t. With colleagues at the National Institutes of Health, Harvard Medical School, and the University of Washington, the team examined a group of children in Tanzania who had been studied since shortly before their birth. First researchers took blood samples of 23 2-year-old children (the age at which resistance to malaria typically develops); 12 were resistant to the disease, as evidenced by the small number of parasites in their blood. To see whether these 12 had unique, protective antibodies, the team checked the blood plasma—the clear, antibody-containing fluid from all children—against a set of Plasmodium genes known to be turned on when the parasite infects the blood.Of the proteins produced by about 3 million possible genes, antibodies in the symptom-free children’s blood latched on to just three, the team reports online today in Science. One gene produces a protein known to help the parasite infect red blood cells and is already under study as a target for a vaccine. Another, previously unknown gene—when the investigators worked out its protein’s structure and studied it in tissue culture—proved to do just the opposite: The protein helped the schizont leave the infected blood cell.”At first, this didn’t make sense. We checked the results three times,” Kurtis says. Apparently, antibodies to this protein protected against malaria by trapping the schizont inside the red blood cell — not by preventing it from infecting new ones. The researchers checked the larger group of study participants. Of about 450 children, about 6% had antibodies to the protein; none of these children developed severe malaria (defined as difficulty breathing, convulsions, high fever, low blood sugar, or severe anemia). When the researchers checked blood samples drawn from a group of teenagers in an unrelated study in Kenya, they found that blood containing the antibody had only about half as many parasites as did samples without it.Finally, Kurtis and colleagues used the antibody to develop a vaccine candidate that they gave to mice infected with a particularly lethal form of malaria. The vaccinated animals lived almost twice as long, and, in one trial, had about one-fourth as many parasites as untreated mice. Kurtis says a vaccine that exploits the antibody’s ability to imprison Plasmodium within blood cells would have more time to work with than one that tries to block reinfection. “The parasite infects a new cell within about 15 seconds, so a vaccine to prevent that action would have to work immediately,” he says. Infected blood cells are removed by the immune system, he explains.”It’s a very elegant approach,” says David Lanar, a parasitologist at the Walter Reed Army Institute of Research in Silver Spring, Maryland. After the few seconds that Plasmodium takes to invade a previously uninfected red blood cell, it’s hidden from any antibody, he explains. When the new cell is infected, however, the membrane becomes leaky for several hours before the schizonts burst out again, giving larger molecules like an antibody or vaccine a chance to get in. A vaccine that keeps the schizonts trapped would shift the timeline in the patient’s favor, he says.A vaccine based on this approach would need to work in tandem with others aimed at different parts of the cycle, Kurtis cautions. The strategy wouldn’t eliminate the parasite, only reduce it to levels that can ease the symptoms, he explains.”At this stage of the game, that’s a good thing,” Lanar says. No treatment breaks the cycle of infection between humans and mosquitos, he says. The next best thing is to reduce the number of clinical symptoms. “The number of parasites in your blood determines how sick you will be.” A vaccine would be especially effective in people who have never been exposed to the disease before, or who lost their childhood immunity by leaving malaria-stricken areas, Lanar says, because these groups are more vulnerable to very severe forms of the illness than those who are partially immune. As a next step, Kurtis’s group is conducting a study of the vaccine in nonhuman primates. If it’s successful, the team will begin clinical trials in humans.*Update, 23 May, 12:12 p.m.: This article has been updated to clarify that as the red blood cell membrane grows leaky to allow the schizonts to escape, it provides an opportunity for treatments to enter.*Correction, 27 May, 4:57 p.m.: An earlier version of the caption for this article inaccurately described the image. The malaria parasite takes up almost the whole red blood cell; the dark, rodlike shapes are bits of hemoglobin that it has digested.
On the heels of several mishaps involving deadly pathogens, U.S. officials are reconvening an expert advisory panel that hasn’t met in nearly 2 years. But the government has also dismissed 11 of the original members of the 23-person panel, called the National Science Advisory Board for Biosecurity (NSABB).“We had no inkling it was going to happen this way,” says Paul Keim, a pathogen genomics researcher at Northern Arizona University in Flagstaff who formerly chaired NSABB and has been on the panel since it was formed in 2005. The 11 members learned they were being dismissed Sunday evening in an e-mail from the board’s executive director, Mary Groesch, who works at the U.S. National Institutes of Health (NIH), NSABB’s overseer. The e-mail prompted this tweet from NSABB member Michael Imperiale of the University of Michigan, Ann Arbor: “#NIH just gave remaining inaugural NSABB members pink sheets. Bizarre time to eliminate all institutional memory.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The e-mail, which ScienceInsider obtained, cheerily informs Imperiale, Keim, and the other original NSABB members that the board will be reconvening in the fall without them. “I wanted to tell you that a new slate of NSABB members has been approved as your replacements, and thus your service on the board is ending,” Groesch wrote. “Since you have all been so gracious as to extend your service for several years beyond your initial term, this may come as welcome news!”NSABB advises and guides the U.S. government about “dual use” research that involves biological agents that could be used as bioweapons. In 2011, it became embroiled in heated debates about “gain-of-function” experiments with the deadly avian influenza virus H5N1 that made it more transmissible in mammals. Last week, Tom Frieden, director of the U.S. Centers for Disease Control and Prevention, held an unusual press conference to discuss three separate, recent mistakes involving lab safety with smallpox, influenza, and anthrax. He said such breaches “should never happen.”Original board member Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, Twin Cities, said he had expected to serve until sometime in 2015. “I don’t know why they do or don’t do things at the NSABB,” Osterholm told ScienceInsider. “I gave up some time ago trying to predict that.” The board has 12 other members who apparently are continuing.An NIH representative said: “It is routine for federal advisory committees to rotate their membership over time so that fresh and diverse perspectives can be brought to bear on the committee’s deliberations. Typically, only a portion of the board is rotated off at a time, so that the NSABB has members with ‘institutional memory,’ as well as individuals with new perspectives. Under special circumstances, membership terms can be extended, though they cannot be extended indefinitely. The terms of the individuals who received notification that their service on the NSABB had come to an end, had been renewed several times. The last time member terms were extended, those extensions were to last until replacement members could be found up until 2015, but not necessarily extending to that date, if less time was required for replacement members to be appointed. … The NSABB roster including new members will be publicly available prior to the next NSABB meeting.”NSABB last met in November 2012, and Osterholm said his last contact with NIH about the panel was in the spring of 2013. “We got one single e-mail saying NSABB had re-upped its charter,” Osterholm says. “That’s the only communication we had in 2 years at a time when the issues we’ve been confronting have been front and center. I don’t understand it.”Arturo Casadevall of the Albert Einstein College of Medicine in The Bronx, New York, says he expected to be replaced, but not so abruptly. The real surprise, he says, “is that all the members who have been through the H5N1 debates have been replaced at the same time” and that the news came on a Sunday evening “right after a week of all these headlines.” He adds that some of the remaining members “are very experienced.”Keim says the newly reconstituted NSABB has its work cut out for it. “I hope that the U.S. government effectively uses the NSABB to address the shortcomings associated with the three incidents,” he says.With reporting by Jocelyn Kaiser.*Update, 15 July, 2:50 p.m.: This article has been updated to include a response from NIH.
European plane manufacturer Airbus and its subsidiary Navblue today said they have signed contracts with two Indian startups – Neewee and Eflight – to build innovative solutions that can be enhanced to meet the firm’s as well as industry needs.The startups were part of the five startups chosen a year back from the second season of the Airbus Bizlab technology acceleration programme, which attracted 137 applications from nine countries, a release issued by the European firm said.Read it at India TV Related Items